Shortly after taking the Oath of Office, President Obama made food safety a domestic priority. He called recent national outbreaks of food-borne illnesses a “troubling trend” and a “risk to public health.”

But more than a year later, the Obama administration has yet to fill post of chief food safety official at the Department of Agriculture. He just nominated someone though, Elizabeth Hagen, 40, a person few in the field of food safety had heard of before the announcement.

Hagen, a physician, has never published a word on the subject of food safety. She spent much of her career as a clinician and educator in the field of infectious diseases. She left practice 4 years ago for the USDA, where rose quickly through the department’s Food Safety and Inspection Service.

“Consumer advocates who work closely with [the Department of Agriculture] on policy issues have had limited direct experience with Dr. Hagen,” said the Consumer Federation of America in a release cited by the Washington Post.

Hagen was tapped for the post after the Administration approached at least two other people. Last February for example, it vetted and offered the job to Mike Doyle, a nationally recognized microbiologist. That nomination collapsed after Doyle refused to divest his financial interest in an effort to commercialize a microbial wash for meat.

Whoever fills the position will oversee the safety of meat, poultry and eggs, which comprise 20% of the nation’s food supply.

Last year, there were 13 recalls of beef products contaminated with E. coli. Already this year, there have been six recalls of tainted meats, including an ongoing situation with salami that has sickened hundreds in 40 states.

Since Michael Sokolove’s “Warrior Girls” brought the matter public attention, many people know that young women athletes are in the midst of an epidemic of knee injuries, including the most dreaded of them all: a tear of the  anterior cruciate ligaments (ACL). In fact girls are three to eight times more likely than boys to sustain that injury.

This stunningly high ratio says the issue goes beyond the fact that girls participate in competitive sports as much as boys do. Given only that, the ratio should be even. The real problem, it turns out, has to do with anatomical and physiological differences between girls and boys.

Girls have thinner ACLs for example. And their pelvises are wider, which has the effect of putting more stress on the knee ligaments during both normal and recreational activities. The anatomy of their femurs (the large, upper leg bone) favors fraying of the ACL. And as well, some female reproductive hormones make their ACLs more lax. 

The epidemic has spawned a host of workouts and training programs designed to help prevent knee injuries in young female athletes. These programs focus on strengthening muscles like the quadriceps that help support the knee, and the core muscles which help stabilize the body during stops and starts, which are so often the times when ACL injuries occur.

The programs have different time requirements, but a 45 minute session, twice a week is  typical.  Also included in most sessions are tips about landing softly and using multiple joints (ankle, knee, hip) for bracing against falls and the like.

“You can’t make an ACL bigger,” Trent Nessler, executive director of Baptist Sports Medicine in Nashville told the Washington Post. “So what we tend to look at is what factors can you affect through training.”

Nessler asserts that girls who participate in these programs can reduce their risk of knee injuries by up to 88%…and even if he’s half right, that seems like something worth doing.

China, not the US, holds the dubious distinction of having the highest number of private computers that have been commandeered by hackers with malicious intent, according to a report by McAfee, an Internet security firm.

MaCafee monitors Internet-based threats targeting computers in 120 countries. It found that in the fourth quarter of last year, about 1,095,000 computers in China and 1,057,000 in the US had been infected.

Those numbers don’t count the roughly 10 million computers in each country that had previously been infected.

Infected, or “zombie” computers are typically linked together as botnets and then used to send spam e-mail or launch Denial of Service attacks on Web sites.

McAfee suggested that Chinese computers are particularly vulnerable to hackers since software piracy is common there, and computer users frequently do not download patches for their machines.

In a recent speech about Internet freedom, Secretary of State Hillary Rodham Clinton suggested that the Internet is a “global networked commons” for which “norms of behavior” ought to be developed by nations.

“An attack on one nation’s networks can be an attack on all,” she said. “Countries or individuals that engage in cyberattacks should face consequences and international condemnation.”

The US will have trouble heeding Clinton’s call for accountability and norms because it has so many infected computers. “The government could crack down on botnets, but doing so would raise the cost of software or Internet access and would be controversial,” Harvard Law professor Jack Goldsmith  wrote in the Washington Post.

“So it has not acted, and the number of dangerous botnet attacks from America grows.”

Older moms have a greater risk of giving birth to a child with autism, according to a study by scientists at UC Davis. 

To reach this conclusion, Janie Shelton and colleagues reviewed all births in California during the 1990s.

They found that the risk of having a child with autism jumped 18% for each 5-year increment in maternal age. A 40-year-old woman had a 50% higher risk of having an autistic child than a 25 year-old woman.
 
Previous research had identified increased paternal age as a risk factor, but this one, by far the largest of its kind, showed that father’s advanced age matters only if the mom is under 30. For older moms, the risk is predicted solely by maternal age.
 
“This study challenges a current theory in autism epidemiology that identifies the father’s age as a key factor in increasing the risk of having a child with autism,” Janie Shelton, the study’s lead author told BurrillReport. “While maternal age consistently increases the risk of autism, father’s age only contributes an increased risk when the mother is under 30 years old.”
 
“We still need to figure out what it is about older parents that puts their children at greater risk for autism and other adverse outcomes, so that we can begin to design interventions,” said Irva Hertz-Picciotto the senior author on the study.

In this regard, UC Davis scientists reported in 2008 that they found antibodies to fetal brain protein in some mothers of children with autism, but not in the mothers of normal children. Others speculate that certain environmental toxins accumulate in the body with age and may play a role as well.

The write-up appears in Autism Research.

Two weeks ago, the prestigious medical journal Lancet retracted a 1998 article that purported to show a link between childhood vaccines and autism. The article stimulated a decade-long debate about vaccine safety, and the Lancet’s retraction effectively ended reasonable scientific discourse on the subject: the vaccines are safe.

Ten of 13 authors of the paper had issued a partial retraction 6 years ago, but the first author, Andrew Wakefield, did not. 

Wakefield’s study had focused on 12 children that had gastrointestinal problems. Eight had symptoms that their parents or a doctor thought were caused by the MMR vaccine, and 9 exhibited autistic behaviors.

That study triggered widespread concern that measles-mumps-rubella vaccine caused autism. Parents decided against immunizing their children as a result. Roughly 2.1% of US children weren’t immunized with the MMR vaccine in 2000, nearly triple the rate of 0.77% in 1995, according to a study in Pediatrics.

This occurred despite the publication of several subsequent studies which showed that vaccines were safe. The most notable among these were a 2004 review of the literature by the Institute of Medicine and a 2008 study by the CDC which looked specifically at children with GI problems.

“This retraction by the Lancet came far too late,” Paul Offit, chief of infectious diseases at Children’s Hospital of Philadelphia told the Wall Street Journal. “It’s very easy to scare people; it’s very hard to unscare them.”

The Lancet pulled the plug after a UK-based health care regulator concluded the Wakefield study was bogus. The General Medical Council’s report included allegations of ethical violations by some investigators, including “cherry-picking” children for the study, rather than taking kids as they presented randomly to the hospital, as had been implied in the paper.

Fully 8 years after the anthrax attacks of 2001 showed that bioterrorism can happen in the US, the nation remains woefully unprepared for a large-scale attack, according to a Congressional Commission.

The WMD Commission evaluated the government’s performance in 17 key areas. It nailed the White House and Congress with an “F” for not creating a rapid-response capability to handle disease outbreaks from bioterrorism, or providing adequate oversight of security and intelligence agencies.

As evidence, the Commission cited the government’s stuttering response to the swine flu epidemic. It pointed fingers at several administrations and branches of government.

In other news, the panel handed out “As” to government programs that secured dangerous viruses and bacteria, and to the Obama administration’s reorganization of the National Security Council so that it could handle other threats from weapons of mass destruction.

The Commission’s report cited in particular the White House’s efforts to strengthen international controls on nuclear technology and components.

“Each of the last three administrations has been slow to recognize and respond to the biothreat,” former senator Bob Graham (D-Fla.) told the Washington Post. Graham co-chaired the panel with former senator James M. Talent (R-Mo.). “We no longer have the luxury of a slow learning curve when we know al-Qaeda is interested in bioweapons.”

In his State of the Union address last month, President Obama revealed plans to fill many of the gaps that were identified by the Commission. In particular, he wants to improve the performance, scalability and flexibility of drug distribution systems.

According to White House spokesman Nick Shapiro, “the goal is a national capability for the rapid, reliable and affordable production of an array of medical countermeasures against public health threats.”

Voxiva, a Washington DC-based mobile technology firm, has launched a government-sponsored program that uses standard text messaging to educate and encourage healthy habits in pregnant women.

The “Text4baby” program sends tips to expectant mothers who sign up using their cell phones. To participate, women text the word, “baby” (or “bebe” for Spanish speakers) to the number 511411. 

Enrollees receive 3 text messages per week, timed to correspond with the woman’s delivery date. The messages cover nutrition, health maintenance and pregnancy management.

The service is entirely free to end-users thanks to government subsidies and the largesse of the wireless carriers. Launched last month, the service had 6,500 sign-ups in the first day. Before this program, Voxiva offered similar text-based services in the US, but they were not free.

Voxiva has launched more than 150 mobile health campaigns in Africa, India and Latin America, areas characterized by developing economies and/or a scarce supply of physicians. These projects are usually underwritten by governments or pharmaceutical firms. They provide news and treatment tips for people with AIDS, obesity, diabetes and smoking.

One of main goals of Text4baby is to discourage alcohol and tobacco use, habits that increase the risk of premature birth. In the US, one out of 8 babies, or about 500,000 births per year, is born prematurely each year. 

Despite the buzz about health-related apps for the iPhone and other smart phones, text messages are ideal for reaching Text4baby’s most important target group, which includes women that can’t afford smart phones. About 90% of US adults carry a cell phone, and nearly all of them support text messaging.

“Senior moments” like forgetting someone’s name or where you parked your care are common in elderly and even middle-aged folks, so how does one know whether they represent something more serious such as dementia?

“It’s the degree of the problem,” James Lah, an Emory University neurologist recently explained to the Washington Post. “If you forget where you place your keys, that’s common. But if you put them in the refrigerator repeatedly, that’s a problem.”

Other Examples
NORMAL: Forgetting where you parked.
PROBLEMATIC: Forgetting where you parked once a week.

NORMAL: Forgetting a person’s name.
PROBLEMATIC: Forgetting a person’s name and then repeatedly asking him or her, “What’s your name again?”

NORMAL: Inability to program the cable box.
PROBLEMATIC: Forgetting how to turn on the television.

Fast Facts
People begin having memory lapses in their 20s, though few worry about it until they’re into their 50s. Peak performance for human memory occurs at about age 22. By age 50, most people are aware their memory ain’t what it used to be. But they can take heart in this: people’s general knowledge-base increases until at least age 60.

Just 10 minutes of brisk walking per day reduces memory losss and the risk of developing Alzheimer’s disease. Amazing but true.

There is growing evidence that Gingko biloba does not work, and there is some positive, but very early buzz surrounding omega-3 fatty acids and pomegranate juice, of all things.

Democratic lawmakers and watchdog groups resumed demands last week that the Department of Justice should explain how emails from Bush administration lawyers that supported harsh interrogation tactics were lost. The same groups raised concerns that their absence might taint the findings of a recent ethics report which cleared the lawyers of charges that they engaged in professional misconduct.

The emails in question cover a critical period in 2002 when attorneys from Justice prepared a memo that cleared the way for CIA operatives to use waterboarding, sleep deprivation and other techniques against al-Qaeda suspects, according to the Washington Post.

“Why were these critical records deleted? Why were they kept from investigators?” Senate Judiciary Committee Chairman Patrick J. Leahy asked at last week’s hearing.

Acting Deputy Attorney General Gary Grindler responded that the ethics report “does not suggest there is anything nefarious” about the lost emails, but that he had asked a department administrator “to determine what was going on with respect to the archiving of these emails.” “If they are retrievable, I will retrieve them,” Grindler said.

Also last week, the National Archives asked why Justice had not notified it about the missing emails before the ethics report was released. And Citizens for Responsibility and Ethics in Washington has asked Justice to launch a criminal inquiry into the lost emails.

Months ago in an internal review, Justice’s Office of Professional Responsibility concluded that former department lawyers John Yoo and Jay Bybee had committed misconduct in preparing those emails and memos. That decision was later overruled by Associate Deputy Attorney General David Margolis who found instead that the lawyers had exercised poor judgment.

At the last week’s Senate hearing Grindler said that Margolis’ ruling was made “without interference” by senior Justice Department officials.

The Massachusetts anesthesiologist accused of cooking up data for use in trials of pain medications has agreed to plead guilty to criminal charges in a deal with federal prosecutors.

Scott Reuben, who had been among the nation’s most respected investigators on the subject, had been charged with one count of healthcare fraud.

Reuben’s trouble began last year, when an internal audit conducted by Baystate Medical Center in Springfield, Mass., revealed he fabricated data for 21 studies he had conducted during the last 15 years.

The criminal charge had focused on one of these, a trial of Celebrex as part of a “multimodal” pain regimen for knee surgery. The study showed the drug was effective and was published in 2007 in Anesthesia & Analgesia.

“In fact,” the prosecution wrote in a court filing, “Reuben had not enrolled any patients into that study, and the results reported…to Anesthesia & Analgesia were wholly made up by Reuben .”

Had he not copped a plea, Reuben could have spent 10 years behind bars and been fined $250,000. The plea convinced prosecutors to recommend lighter penalties.

After Baystate spilled the beans, journals that had published his tainted articles retracted them.

Baystate terminated its contract with Reuben last spring. At the same time, he reportedly agreed to suspend his practice and was stripped of a professorship at Tufts.

Several widely accepted medical beliefs need to be re-examined in light of the scandal. Topping the list are the effect of COX-2 inhibitors on bone healing and the role of multimodal analgesic regimens in managing chronic pain.

With respect to the former, Reuben’s studies suggested the drugs had no effect on bone fusion, a finding that was contrary to the results of several animal studies.