Resveratrol: Is the Honeymoon Over?

December 27th, 2010 | Sources: Fierce Biotech, Myeloma Beacon

Subjects:

Resveratrol, a naturally-occurring antioxidant found in blueberries, red grapes and red wine, had become a press-magnet over the last few years after studies showed it activated so-called Sirt1 metabolic pathways which control the differentiation, aging and death of mammalian cells.

lifesavers 200x300 Resveratrol: Is the Honeymoon Over?The studies prompted scientists to speculate that resveratrol can be leveraged to fight cancer or even create a modern-day Fountain of Youth.

Amid the excitment, GlaxoSmithKline shelled-out $720 million to purchase Sirtris Pharmaceuticals, a Boston-based company that owned key patents in the area and that was headed by a controversial Harvard researcher, David Sinclair. Sinclair reportedly pocketed $8 million in the deal.

Alas, things haven’t gone well for GSK since the purchase. Last month in fact, the drug giant announced it was pulling the plug on further development of SRT 501, one of the proprietary resveratrol formulations it acquired from Sirtris.

GSK officials said at the time that the drug’s potential to cause harm outweighed any possible benefits, at least in relation to the treatment of multiple myeloma, a bone marrow cancer.

The announcement came a few months after GSK shut down a Phase 2 trial of the compound when several patients developed kidney failure.

The Myeloma Beacon, a blog that follows scientific advancements relevant to multiple myeloma, first broke the story. A GSK spokesperson told the Beacon that its decision allows the company to reassign development resources towards other resveratrol compounds with a more favorable risk/benefit ratio. The newer compounds are not being considered as treatments for myeloma.

“Currently, we have two of these latest generation compounds (SRT2104 and SRT2379) in several exploratory clinical trials,” the spokesperson added.

The GSK spokesperson did not indicate why the company decided to bag research on SRT501 altogether. Certainly, it could have continued to assess the compound for efficacy against other diseases.

Earlier scientific claims about resveratrol were based on laboratory studies involving mice and other rodents. GSK’s trial of SRT501 in myeloma patients was the first trial of the drug in humans.


 

Comments

  1. David Emerson | 28/12/10

    I am a long term myeloma survivor- I was diagnosed 3/94. I have been supplementing daily with resveritrol for about 3 years now.

    I view GSK’s problems with resveritrol as a good thing. My understanding is that GSK greatly strengthened resveritol for their clinical trials. It was no surprise to me that people then experienced kidney problems.

    I plan to continue my daily resveritrol supplementation along with curcumin, green tea extract, grape seed extract, wobenzyme enzymes, fish oil, and others. Three years of intense conventional therapies did little for me other than saddle me with many side effects- some permanent.

    David Emerson

  2. drcharles | 31/12/10

    Same story, new disappointing “herb.” In the meantime we should eat, drink, and be merry. Thanks for this important update; I am often asked about this supplement.

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