http://www.pizaazz.com/2009/04/15/dwarfarin/ Healthcare News & More Mon, 30 Jan 2012 09:04:35 +0000 hourly 1 http://wordpress.org/?v=3.2.1 http://www.pizaazz.com/2009/04/15/dwarfarin/comment-page-1/#comment-873 Jeffrey Seguritan Thu, 16 Apr 2009 00:35:08 +0000 http://www.pizaazz.com/?p=4234#comment-873 Less clots, more bleeding--the same banner that plagues prasugrel in comparison to the well-established clopidogrel (Plavix). It was Sanjay Kaul brought up the argument that bleeding risk from prasugrel could not be cleanly isolated even among the high risk groups (>75 yrs, less than 130 lbs, stroke history) identified in the TRITON-TIMI study. Actually, what I found fascinating was the secondary finding from the JUPITER study (http://online.wsj.com/article/SB123837273043767895.html) that showed Crestor to significantly reduce VTE risk by 43% (although the absolute numbers were small--34 vs. 60 in a 15,000 patient trial). Ironically, this might be yet another corroboration of the hypothesis that statins do their magic by targeting inflammation, not cholesterol. Less clots, more bleeding–the same banner that plagues prasugrel in comparison to the well-established clopidogrel (Plavix). It was Sanjay Kaul brought up the argument that bleeding risk from prasugrel could not be cleanly isolated even among the high risk groups (>75 yrs, less than 130 lbs, stroke history) identified in the TRITON-TIMI study. Actually, what I found fascinating was the secondary finding from the JUPITER study (http://online.wsj.com/article/SB123837273043767895.html) that showed Crestor to significantly reduce VTE risk by 43% (although the absolute numbers were small–34 vs. 60 in a 15,000 patient trial). Ironically, this might be yet another corroboration of the hypothesis that statins do their magic by targeting inflammation, not cholesterol.

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