Subjects: R and D
In his 1962 treatise The Structure of Scientific Revolutions, Thomas Kuhn introduced the term “paradigm shift” to describe an abrupt breakthrough in science theory that jump-starts a whole new platform of inquiry, one that could not be envisioned using the older paradigm.
Einstein’s Theory of Relativity was a paradigm shift. So was the discovery in the 19th century that many diseases are caused by bacteria.
The theory is that cancers arise from stem cells. It hadn’t even been appreciated until recently that all human tissue contained stem cells.
The new theory turns the prevailing model of tumorogenesis upside down. Cancer had been thought to result from mutations in fully differentiated cells such as epithelial cells of the bronchi or neurons in the brain. The new theory means it might possible to develop stem cell targeted treatments which might be more effective and less toxic than those developed under the current paradigm.